Clomiphene stimulates the release of hormones needed to cause ovulation.

Clomiphene therapy is typically used for 5 consecutive days early in the menstrual cycle, for 3 to 6 monthly cycles. It may take several cycles to find the right dose to stimulate ovulation. After that dose is determined, a woman will take the drug for at least 3 more cycles. If she does not become pregnant after 6 cycles, it is unlikely that further clomiphene treatment will be successful.

Why It Is Used

For Women-Clomiphene may be prescribed to:

            •           Stimulate ovulation in a woman who does not ovulate or who ovulates irregularly.

            •           Regulate ovulation in a woman who ovulates irregularly and/or is going to have intrauterine insemination or artificial insemination. Clomiphene is sometimes used together with other medicines and infertility treatments.

For Men- Clomiphene may be used to treat low sperm counts (oligospermia- sperm count < 15x 106/ml).

are hormones (LH and FSH) that can be given in an injection to stimulate a woman’s ovaries to produce follicles, which contain an oocyte (egg). Women who have not been able to become pregnant with clomiphene (Clomid®) may be encouraged to try gonadotropins as a next step.

Gonadotropins are two hormones, luteinizing hormone (LH) and follicle stimulating hormone (FSH), which are normally produced by the pituitary gland. These hormones stimulate the ovaries to produce a follicle, which contain an egg (oocyte).

Most gonadotropin preparations used for infertility treatment are created in a laboratory (called recombinant preparations) and must be injected under the skin to be effective. For most women, a preparation containing only FSH injections is recommended. Women who do not have regular menstrual periods and who have very low levels of LH and FSH require a preparation containing both LH and FSH.

IUI is a fertility treatment that uses a catheter to place a number of washed sperm directly into the uterus. The goal of IUI is to increase the number of sperm that reach the fallopian tubes and subsequently increase the chance of fertilization. A semen sample will be washed by the lab to separate the semen from the seminal fluid. A catheter is used to inject the processed sperm directly into the uterus. This process maximizes the number of sperm cells that are placed in the uterus, thus increasing the possibility of conception. The IUI procedure takes little time and involves minimal discomfort.